Genetic Epidemiology of Multiple Sclerosis

Genetic epidemiology of multiple sclerosis.

Epidemiological studies of multiple sclerosis have been performed on almost an industrial scale over the past 90 years. Morbidity statistics have been used to generate aetiological hypotheses, to assess local needs for the provision of services and the allocation of resources, and to define the natural history of the disease. Methodological factors have limited the extent to which the many surv...

Genetic burden mirrors epidemiology of multiple sclerosis.

The prevalence of multiple sclerosis (MS) varies worldwide and, within Europe, decreases with latitude from Scandinavia to the Mediterranean populations. Several explanations have been offered for the prevalence gradient, including environmental factors such as sunlight exposure. However, differences in the frequency of genetic risk factors may well explain an important fraction of variation in...

P 21: Epidemiology of Multiple Sclerosis in Khorasan Razavi Province

Introduction: Multiple Sclerosis is an autoimmune disease which demyelinates neurons. It is the leading cause of non-traumatic disability in young adults in many countries. According to the atlas of MS, the number of patients with MS has increased from 2.1 million in 2008, to 2.3 million in 2013. Although several studies have been done worldwide to clarify the epidemiological patterns of the di...

Genetic epidemiology of Multiple Sclerosis: a review of the literature

Genetic epidemiology: Systemic sclerosis

Systemic sclerosis (SSc) is a multisystem connective tissue disease characterised phenotypically by fibrosis and ischaemic atrophy. Its aetiology is most likely multifactorial. A genetic predisposition to the condition is suggested by reports of familial SSc (a positive family history is the strongest risk factor yet identified), by animal models, and by disease-association studies, in which re...